Atazanavir: What It Is, How to Use It, and What to Watch For

Atazanavir is an antiretroviral drug used to treat HIV‑1 infection. It belongs to the protease inhibitor class, which stops the virus from making new copies. If you or someone you know has been prescribed atazanavir, here’s the nuts and bolts you need to know.

How to Take Atazanavir

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Usually you’ll take atazanavir once a day with a big meal. Food helps your body absorb the medicine better, so skipping the meal can lower the drug’s effectiveness. The typical dose is 300 mg, but doctors may adjust it based on other meds you’re on or your kidney function.

Don’t crush, split, or chew the tablet unless your doctor says it’s okay. Swallow it whole with plenty of water. If you miss a dose, take it as soon as you remember—unless it’s almost time for your next dose, then just skip the missed one. Never double up.

Common Side Effects and When to Call the Doctor

Most people tolerate atazanavir well, but you might notice a few side effects. The most frequent are:

  • Yellowish skin or eyes (jaundice) – caused by a change in bilirubin levels.
  • Headache, nausea, or mild stomach upset.
  • Rash or itching.

If any of these get severe, or if you develop fever, severe abdominal pain, or unexplained bruising, reach out to your healthcare provider right away. Those could signal a more serious reaction.

Atazanavir can raise your cholesterol and triglyceride levels, so getting regular blood work is a smart move. It also interacts with several other drugs, especially antacids that contain aluminum or magnesium. Always tell your pharmacist about every prescription, over‑the‑counter, and supplement you take.

One tricky interaction is with certain heart meds like amiodarone; they can cause dangerous heart rhythm changes. If you’re on any heart medication, your doctor may need to monitor you closely or pick a different HIV regimen.

Finally, if you’re pregnant or planning to become pregnant, discuss options with your doctor. Atazanavir is considered safe during pregnancy, but dosage might need tweaking.

Knowing how to use atazanavir correctly and spotting side effects early can keep your treatment on track and your health stable.

Got more questions? Talk to your prescriber or pharmacist—they’re the best source for personalized advice.

Atazanavir and Sexual Health: Risks, Benefits, and Safe Sex Guidance (2025)

Atazanavir and Sexual Health: Risks, Benefits, and Safe Sex Guidance (2025)

Clear, people-first guidance on atazanavir and sexual health: benefits, risks, ED meds, birth control, pregnancy, U=U, and practical steps to stay safe.